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Overview

Since the beginning of the scientific treatment of cancer in the 19th century, there have been unexplained accounts of suddenly-cured individuals. Many of these events involved the patient catching an illness accompanied by a high fever. Since then, there have been numerous studies conducted on the efficacy of fever in treating cancer. 

It is evident that in a feverous state, the body naturally releases anti-cancerous substances. Therapeutic hyperthermia or fever therapy is the process of artificially raising one’s core temperature. High internal temperatures kill cancer cells without damaging healthy tissue, making therapeutic hyperthermia a safe treatment effective in shrinking malignant tumors. 

Process of Therapeutic Hyperthermia

During therapeutic hyperthermia, a patient is exposed to temperatures of around 113°F (45°C) until the body reaches a high fever. The body is then safely held in a feverous state for 3-4 hours while being closely monitored for signs of stress. The treatment is repeated once a week for 3 weeks as part of our most effective treatment plan against cancer. 

A high fever aims to amplify the immune system’s response against cancer, increasing the efficacy of other treatments such as therapeutic cancer vaccinations. For this reason, we utilize therapeutic hyperthermia as a supplemental therapy alongside cancer vaccinations and aspirin, which make up our three core therapies against cancer. 

Unlike personalized vaccines against cancer and aspirin therapy, therapeutic hyperthermia cannot be conducted at the patient’s home. To participate in our therapeutic hyperthermia program, patients need to come to our clinic for a full 3 weeks. 

History of Therapeutic Hyperthermia: How Far We’ve Come

Therapeutic hyperthermia is a treatment with ancient roots. In those times, heat had a sacral meaning, associated with the healing power of the sun. The Egyptians are known to have conducted hyperthermia treatments for various diseases as early as 2500 BC! However, it was the Greeks who were among the first civilizations to utilize hyperthermia as a conscious cure for cancer. 

This continued through to the 19th century where high fevers were linked to tumor shrinkage and cancer regression. This pattern resulted in the time’s leading scientists to intentionally infect their cancer patients with diseases, hoping to induce fevers. Doctors would apply dirty bandages or the blood of malaria-infected individuals to the cancer patient’s open wounds to raise their core body temperature. 

Infectious fever therapy carried on for a few years until doctors finally realized that this treatment was relatively unpredictable and unsafe. Each patient would react to toxins differently, ultimately resulting in physicians abandoning infectious hyperthermia as an effective therapy. 

In further years, scientists worked on developing safer methods of artificially raising one’s core body temperature, eventually leading to today’s advanced hyperthermia process used in clinics like ours!

Studies of Therapeutic Hyperthermia

  1. Behrouzkia, Zhaleh et al. “Hyperthermia: How Can It Be Used?.” Oman medical journal vol. 31,2 (2016): 89-97. doi:10.5001/omj.2016.19
  2. Skitzki, Joseph J et al. “Hyperthermia as an immunotherapy strategy for cancer.” Current opinion in investigational drugs (London, England : 2000) vol. 10,6 (2009): 550-8.
  3. DeNardo, Gerald L, and Sally J DeNardo. “Update: Turning the heat on cancer.” Cancer biotherapy & radiopharmaceuticals vol. 23,6 (2008): 671-80. doi:10.1089/cbr.2008.0591
  4. Kobayashi Y, Itoa Y, Ostapenko VV, Sakai M, Matsushita N, Imai K, Shimizu K, Aruga A,Tanigawa K Fever-range whole-body heat treatment stimulates antigen-specificT-cell responses in humans Immunology Letters 162 (2014) 256–261 https://www.ncbi.nlm.nih.gov/pubmed/25256774
  5. Kraybill WG, Olenki T, Evans SS, Ostberg JR, O’Leary KA, Gibbs JF, Repasky EA. A phase I study of fever-range whole body hyperthermia (FR-WBH) in patients with advanced solid tumours: correlation with mouse models. Int J Hyperthermia. 2002 May-Jun;18(3):253-66 https://www.ncbi.nlm.nih.gov/pubmed/12028640
  6. Repasky EA, Evans SS, Dewhirst M: Temperature Matters! And Why it Should Matter to Tumor Immunologists. Cancer Immunol Res. 2013 Oct 1; 1(4) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904378/
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